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KMID : 0043319960190050386
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Archives of Pharmacal Research
1996 Volume.19 No. 5 p.386 ~ p.389
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A Novel Ocular Delivery System for Phenylephrine Hydrochloride
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Durrani A.M.
Jamshaid M.
Kellaway I.W.
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Abstract
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The in vivo behaviour of phenylephrine hydrochloride in different vehicles like gels of Carbopol , Carbopol and latex system of cellulose acetate hydrogen phthalate(CAHP) was evaluated by measuring the reduction in intraocular pressure and the mydriatic activity. The parameters that haave been utilised to assess the performance of the formulations were the area under the curve (AUC), the maximum mydriasis , ethe time of maximum response and the duration of activity (D). The influence of viscosity and mucoadhesion on the bioavailability parameters has also been investigated. Carbopol 934P and CAHP formulations showed prolonged duration of action and greater AUC compared to Carbopol 907 aqueous solution(P<0.05).
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KEYWORD
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Carbopol, Cellulose acetate hydrogen phthalate(CAHP), Phenylephrine hy-drochloride, Intraocular pressure(I OP), Rabbit
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